Lauren Tom's first role in television was that of Miko Wakamatsu on The Facts of Life. She subsequently appeared on The Equalizer, thirtysomething, Quantum Leap, Chicago Hope, Homicide: Life on the Street, Grace Under Fire, Ross' girlfriend Julie on Friends and a starring role in DAG, The Division, Monk, My Wife and Kids, Barbershop: The Series, Grey's Anatomy, The Closer, and Men in Trees. She also had an acting role in a bonus feature on the Futurama: Into the Wild Green Yonder DVD.

Voice acting

Tom began vocal work in the animated series Superman: The Animated Series (as Angela Chen). From there Lauren had minor roles on Pinky and the Brain , Extreme Ghostbusters and The Zeta Project before landing her lasting roles on King of the Hill and later Futurama.

She has also lent her voice to All Grown Up!, Rocket Power, Max Steel, Batman Beyond, Justice League Unlimited, Kim Possible, Numbuh Three(and Adult Numbuh Three in the episode Operation: I.N.T.E.R.V.I.E.W.S.)and Numbuhs 44 and 45 on Codename: Kids Next Door, Teen Titans, Yan Lin, Susan, Alchemy on W.I.T.C.H., The Replacements,Legion of Super Heroes, Jake's mom, Counselor Chang on American Dragon: Jake Long, and Avatar the Last Airbender (as Joo Dee) and she does Julie's Mom on Puzzle Place.

Other animated movies Tom has voiced include Mulan II, Kim Possible: The Secret Files, Kim Possible Movie: So The Drama, Batman Beyond: Return of the Joker, the four Futurama movies Bender's Big Score, The Beast with a Billion Backs, Bender's Game, and Into the Wild Green Yonder.