Bursa adalah pusat industri automatif di Turki.[8][9] Kilang-kilang pengeluar kereta seperti Fiat, Renault dan Karsan, selain pengeluar komponen automatif seperti Bosch, Mako, Valeo, Johnson Controls dan Delphi aktif di bandar ini selama berdekad-dekad. Industi tekstil dan makanan juga bertapak di sini seperti Coca Cola, Pepsi Cola dan jenama-jenama minuman lain. Selain itu, industri makanan segar dan bertin juga terletak dalam sebuah zon industri yang tersusun.

Perbadanann industri 10 teratas di wilayah Bursa adalah:[10]

• Oyak Renault
• Tofaş Fiat
• Bosch
• Borçelik
• Türk Prysmian Kablo
• Produk Tenusu Sütaş
• Bis Enerji
• Zorlu Enerji
• Borusan Mannesmann Boru
• Componenta Döktaş

Selain industri automotif yang besar, Bursa juga mengeluarkan produk tenusu dalam jumlah yang besar (oleh Sütaş'),[11] makanan diproses (oleh Tat),[12] dan minuman (oleh Uludağ).[13]

Traditionally, Bursa was famous for being the largest center of silk trade in the Byzantine and later the Ottoman empires, during the period of the lucrative Silk Road. The city is still a major center for textiles in Turkey and is home to the Bursa International Textiles and Trade Center ([Bursa Uluslararası Tekstil ve Ticaret Merkezi] error: {{lang}}: teks mempunyai penanda italik (bantuan), or BUTTIM). Bursa was also known for its fertile soil and agricultural activities, which have decreased in the recent decades due to the heavy industrialization of the city.

Bursa is a major center for tourism. One of the most popular skiing resorts of Turkey is located at Mount Uludağ, just next to the city proper. Bursa's thermal baths have been used for therapeutical purposes since Roman times. Apart from the baths that are operated by hotels, Uludağ University has a physical therapy center which also makes use of thermal water.